Probiotics are living microorganisms that are increasingly used as gastrointestinal therapeutics by virtue of their innate or engineered genetic function. Unlike abiotic therapeutics, probiotics can replicate in their intended site, subjecting their genomes and therapeutic properties to natural selection.
According to a new study from Washington University School of Medicine in St. Louis, probiotics evolve and behave differently in individuals with disparate microbiomes and diets. Thus, probiotics can evolve inside the body and have the potential to become less effective and sometimes even harmful. This study opens avenues for personalizing probiotic-based medicine.
Link to the complete article: https://source.wustl.edu/2019/03/probiotic-bacteria-evolve-inside-mices-gi-tracts/
Source: Washington University in St. Louis
Original Study DOI: 10.1016/j.chom.2019.02.005